The Nicotinic Agonist Cytisine: The Role of the NH···N Interaction
Abstract We report a detailed structural study of cytisine, an alkaloid used to help with smoking cessation, looking forward to unveiling its role as a nicotinic agonist. High-resolution rotational spectroscopy has allowed us to characterize two different conformers...
Synthesis, Properties and Spatial Structure of 4-[(3,5-Dimethyl-1,2-oxazol-4-yl)sulfonyl]cytisine
Abstract This article has studied the synthesis of a new derivative of the known alkaloid cytisine contained in the seeds of plants of Cytisus laburnum L. and Thermopsis lanceolata R.Br., both of the Lugiminosae family. The new compound has been obtained from two...
Cytisine – From the Past to the Future
Abstract Introduction: Neuronal nicotinic acetylcholine receptors are ligand-gated ion channel receptors, distributed throughout central nervous system, as well as in peripheral ganglia and some non-neuronal cells. Cytisine, a qulinolizidine alkaloid, could be...
Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors
Abstract Covering: up to the end of 2011. This review covers classical and modern structural modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and analogues, and the pharmacology of these compounds, with emphasis on their interactions...
Cytisine is neuroprotective in female but not male 6-hydroxydopamine lesioned parkinsonian mice and acts in combination with 17-β-estradiol to inhibit apoptotic endoplasmic reticulum stress in dopaminergic neurons
Abstract Apoptotic endoplasmic reticulum (ER) stress is a major mechanism for dopaminergic (DA) loss in Parkinson's disease (PD). We assessed if low doses of the partial α4β2 nicotinic acetylcholine receptor agonist, cytisine attenuates apoptotic ER stress and exerts...
Cytisine versus varenicline for smoking cessation in New Zealand indigenous Māori: a randomized controlled trial
Abstract Aim: To determine whether cytisine was at least as effective as varenicline in supporting smoking abstinence for ≥ 6 months in New Zealand indigenous Māori or whānau (extended-family) of Māori, given the high smoking prevalence in this population. Design:...
Cytisine-like alkaloids from the seeds of Ormosia hosiei Hemsl. et Wils
Abstract Two new cytisine-like alkaloids, hositisines C (1) and D (2), were isolated from the seeds of Ormosia hosiei along with four known compounds, (-)-tinctorine (3), β-adenosine (4), 2'-deoxyadenosine (5), and 7, 2', 4'-trihydroxy-5-methoxyisoflavanone (6). Their...
The Effect of Cytisine vs Varenicline on Smoking Cessation-Reply
The Effect of Cytisine vs Varenicline on Smoking Cessation-Reply. Source: https://pubmed.ncbi.nlm.nih.gov/34751713/?rand=178
The Effect of Cytisine vs Varenicline on Smoking Cessation
The Effect of Cytisine vs Varenicline on Smoking Cessation. Source: https://pubmed.ncbi.nlm.nih.gov/34751716/?rand=178
Is cytisine contraindicated in smoking patients with coronary artery disease after percutaneous coronary intervention?
Abstract Background: Cytisine is contraindicated, and its effects have not been evaluated in patients with coronary artery disease (CAD). Aims: The safety, feasibility, and short-term efficacy of cytisine for smoking cessation were evaluated in active smokers with CAD...
Cytisine Exerts an Anti-Epileptic Effect via α7nAChRs in a Rat Model of Temporal Lobe Epilepsy
Abstract Background and Purpose: Temporal lobe epilepsy (TLE) is a common chronic neurological disease that is often invulnerable to anti-epileptic drugs. Increasing data have demonstrated that acetylcholine (ACh) and cholinergic neurotransmission are involved in the...
Effect of Cytisine vs Varenicline on Smoking Cessation: A Randomized Clinical Trial
Abstract Importance: Cytisine is more effective than placebo and nicotine replacement therapy for smoking cessation. However, cytisine has not been tested against the most effective smoking cessation medication, varenicline, which is associated with adverse events...